Welcome!
Comprehensive Resistance Prediction for Tuberculosis: an International Consortium is a world-wide collaboration between tuberculosis (TB) research institutions all over the world to achieve better, faster and more targeted treatment of multidrug-resistant TB via genetic resistance prediction.
Twitter: @CRyPTICproject
About the project
CRyPTIC’s aim is to help improve control of tuberculosis and facilitate WHO’s End TB Strategy by better, faster and more targeted treatment of drug-resistant tuberculosis via genetic resistance prediction, paving the way towards universal drug susceptibility testing (DST).
Our ultimate goal is to achieve sufficiently accurate genetic prediction of resistance to most anti-tuberculosis drugs, so that whole genome sequencing can replace culture-based DST for TB. This will enable rapid-turnaround near-to-patient assays to revolutionise MDR-TB identification and management. This project is funded by MRC Newton Fund, Wellcome Trust, and Bill & Melinda Gates Foundation.
Updates
New logo celebrating the release of the CRyPTIC papers
To celebrate the release of the CRyPTIC dataset and the nine manuscripts deposited in preprint servers, we've made a new CRyPTIC logo that includes all the names of the people in the CRyPTIC project.
Press release – Largest ever global study of tuberculosis identifies genetic causes of drug resistance
Using cutting-edge genomic sequencing techniques, researchers at the University of Oxford have identified almost all the genomic variation that gives people resistance to 13 of the most common tuberculosis (TB) drug treatments. The Comprehensive Resistance
New publication: Structure of MmpL3 protein
Oliver Adams, as part of his DPhil studies in Simon Newstead's group at the University of Oxford, has resolved the structure of MmpL3 which is the only essential member of the mmpL family of genes.