Welcome!
Comprehensive Resistance Prediction for Tuberculosis: an International Consortium is a world-wide collaboration between tuberculosis (TB) research institutions all over the world to achieve better, faster and more targeted treatment of multidrug-resistant TB via genetic resistance prediction.
Twitter: @CRyPTICproject
About the project
CRyPTIC’s aim is to help improve control of tuberculosis and facilitate WHO’s End TB Strategy by better, faster and more targeted treatment of drug-resistant tuberculosis via genetic resistance prediction, paving the way towards universal drug susceptibility testing (DST).
Our ultimate goal is to achieve sufficiently accurate genetic prediction of resistance to most anti-tuberculosis drugs, so that whole genome sequencing can replace culture-based DST for TB. This will enable rapid-turnaround near-to-patient assays to revolutionise MDR-TB identification and management. This project is funded by MRC Newton Fund, Wellcome Trust, and Bill & Melinda Gates Foundation.
Updates
New paper: Estimating genetic adaption in 10,000 M. tuberculosis genomes
Daniel Wilson, one of the CRyPTIC partners, has recently published a paper where he introduces a new approach, genomegaMap, which estimates the ratio of non-synonymous to synonymous mutations (usually referred to as dN/dS) at sites
CRyPTIC inoculates its 15,000th microtitre plate
Sometime in November 2019, the 15,000th 96-well microtitre plate was inoculated with M. tuberculosis. Since each plate contains 13 different antibiotics used to treat tuberculosis this is a large and comprehensive antibiotic susceptibility dataset. The
Fifth Annual CRyPTIC Meeting in Hyderabad
The fifth CRyPTIC annual meeting took place in Hyderabad on Sat 26 and Sun 27 Oct 2019. Consortium partners were updated on the various analysis projects and a General Assembly was held to discuss the