Welcome!
Comprehensive Resistance Prediction for Tuberculosis: an International Consortium is a world-wide collaboration between tuberculosis (TB) research institutions all over the world to achieve better, faster and more targeted treatment of multidrug-resistant TB via genetic resistance prediction.
Twitter: @CRyPTICproject
About the project
CRyPTIC’s aim is to help improve control of tuberculosis and facilitate WHO’s End TB Strategy by better, faster and more targeted treatment of drug-resistant tuberculosis via genetic resistance prediction, paving the way towards universal drug susceptibility testing (DST).
Our ultimate goal is to achieve sufficiently accurate genetic prediction of resistance to most anti-tuberculosis drugs, so that whole genome sequencing can replace culture-based DST for TB. This will enable rapid-turnaround near-to-patient assays to revolutionise MDR-TB identification and management. This project is funded by MRC Newton Fund, Wellcome Trust, and Bill & Melinda Gates Foundation.
Updates
CRyPTIC ECOFF/ECV paper attracts two letters
The paper we, as a consortium, published last year in Eur Rest J, described the ECOFF/ECV values we had determined for research use. The Editor received two letters about our paper which you can read
CRyPTIC papers covered by CIDRAP
The Center for Infectious Disease Research and Policy (CIDRAP) has written a news story on the two CRyPTIC papers recently published in PLoS Biology. Click here to read more.
Two new publications: Data compendium and GWAS
These two papers, just published in PLoS Biology, are amongst the primary research outputs of the CRyPTIC project. The first, entitled "A data compendium associating the genomes of 12,289 Mycobacterium tuberculosis isolates with quantitative resistance