Welcome!
Comprehensive Resistance Prediction for Tuberculosis: an International Consortium is a world-wide collaboration between tuberculosis (TB) research institutions all over the world to achieve better, faster and more targeted treatment of multidrug-resistant TB via genetic resistance prediction.
Twitter: @CRyPTICproject
About the project
CRyPTIC’s aim is to help improve control of tuberculosis and facilitate WHO’s End TB Strategy by better, faster and more targeted treatment of drug-resistant tuberculosis via genetic resistance prediction, paving the way towards universal drug susceptibility testing (DST).
Our ultimate goal is to achieve sufficiently accurate genetic prediction of resistance to most anti-tuberculosis drugs, so that whole genome sequencing can replace culture-based DST for TB. This will enable rapid-turnaround near-to-patient assays to revolutionise MDR-TB identification and management. This project is funded by MRC Newton Fund, Wellcome Trust, and Bill & Melinda Gates Foundation.
Updates
New publication: BashTheBug!
We enlisted citizen scientists to help us classify the many thousands of photographs of the different samples of M. tuberculosis collected by CRyPTIC growing on different concentrations of antibiotics by launching the BashTheBug project on
New publication: ECOFF/ECVs for 96-well microtitre plates
The CRyPTIC project tested the susceptibility of each sample collected to 13 different antibiotics; since over 20,000 samples were collected, a high-throughput method was required. The consortium chose to use a bespoke dry 96-well microtitre
New publication: WHO catalogue of M. tuberculosis resistance mutations
The World Health Organization published its first catalogue of mutations in M. tuberculosis known to be associated with resistance to a range of antibiotics in June 2021. This paper, just published in Lancet Microbe, describes