Welcome!
Comprehensive Resistance Prediction for Tuberculosis: an International Consortium is a world-wide collaboration between tuberculosis (TB) research institutions all over the world to achieve better, faster and more targeted treatment of multidrug-resistant TB via genetic resistance prediction.
Twitter: @CRyPTICproject
About the project
CRyPTIC’s aim is to help improve control of tuberculosis and facilitate WHO’s End TB Strategy by better, faster and more targeted treatment of drug-resistant tuberculosis via genetic resistance prediction, paving the way towards universal drug susceptibility testing (DST).
Our ultimate goal is to achieve sufficiently accurate genetic prediction of resistance to most anti-tuberculosis drugs, so that whole genome sequencing can replace culture-based DST for TB. This will enable rapid-turnaround near-to-patient assays to revolutionise MDR-TB identification and management. This project is funded by MRC Newton Fund, Wellcome Trust, and Bill & Melinda Gates Foundation.
Updates
BashTheBug passes 4 million classifications
A few days ago our BashTheBug volunteers passed the 4 million classifications mark! The work they are doing is key to improving the accuracy with which our 96-well microtitre plates are read in the CRyPTIC
New paper: Estimating genetic adaption in 10,000 M. tuberculosis genomes
Daniel Wilson, one of the CRyPTIC partners, has recently published a paper where he introduces a new approach, genomegaMap, which estimates the ratio of non-synonymous to synonymous mutations (usually referred to as dN/dS) at sites
CRyPTIC inoculates its 15,000th microtitre plate
Sometime in November 2019, the 15,000th 96-well microtitre plate was inoculated with M. tuberculosis. Since each plate contains 13 different antibiotics used to treat tuberculosis this is a large and comprehensive antibiotic susceptibility dataset. The